Synonyms: RO-0622
Compound class:
Synthetic organic
Comment: Azvudine is a nucleoside analogue that was first identified as an inhibitor of the HIV-1 RNA-dependent RNA polymerase (RdRp) [4]. It has more recently been reported to inhibit RdRp from the SARS-CoV-2 betacoronavirus [5]. The active triphosphate metabolite concentrates in the thymus and peripheral blood mononuclear cells, and oral treatment induces curative mechanisms in preclinical models.
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
4-amino-1-[(2R,3S,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one |
Synonyms ![]() |
RO-0622 |
Database Links ![]() |
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CAS Registry No. | 1011529-10-4 (source: PubChem) |
ChEMBL Ligand | CHEMBL519846 |
GtoPdb PubChem SID | 500839889 |
PubChem CID | 24769759 |
Search Google for chemical match using the InChIKey | KTOLOIKYVCHRJW-XZMZPDFPSA-N |
Search Google for chemicals with the same backbone | KTOLOIKYVCHRJW |
UniChem Compound Search for chemical match using the InChIKey | KTOLOIKYVCHRJW-XZMZPDFPSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | KTOLOIKYVCHRJW-XZMZPDFPSA-N |