Synonyms: Ab969 [US9908939] | axatilimab-csfr | INCA034176 | Niktimvo® | SNDX-6352 | UCB-6352
axatilimab is an approved drug (FDA (2024))
Compound class:
Antibody
Comment: Axatilimab (SNDX-6352, formerly UCB-6352) is a humanized anti-CSF-1R antibody. It was initially developed as an alternative therapeutic modality for the treatment of chronic graft-versus-host disease (GvHD) [2]. Axatilimab targets macrophage-mediated inflammation and fibrosis that cause organ damage in GvHD, by blocking CSF-1R activation by either of its ligands (CSF-1 and IL-34).
Peptide sequences from the axatilimab INN entry align with sequences that are claimed in a UCB Biopharma patent originally filed in 2014 [1]. ![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
Classification ![]() |
|
Compound class | Antibody |
Approved drug? | Yes (FDA (2024)) |
International Nonproprietary Names ![]() |
|
INN number | INN |
10953 | axatilimab |
Synonyms ![]() |
Ab969 [US9908939] | axatilimab-csfr | INCA034176 | Niktimvo® | SNDX-6352 | UCB-6352 |
Database Links ![]() |
|
Specialist databases | |
IMGT/mAb-DB | 942 |
Other databases | |
GtoPdb PubChem SID | 500839907 |
Search PubMed clinical trials | axatilimab |
Search PubMed titles | axatilimab |
Search PubMed titles/abstracts | axatilimab |