Compound class:
Synthetic organic
Comment: Compound 4k is reported to completely block currents through the Orai component of the calcium release activated calcium (CRAC) channel, evaluated as inhibition of NFAT activation and nuclear translocation [1]. Blockade of Orai pore was confirmed in HEK293 cells overexpressing G98S mutant or wild-type Orai1. Compound 4k does not alter the electrophysiological function of TRPM4 and TRPM7 channels. The chemical structure is claimed in patent WO2020180876A1 [2].
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
1-(cyclopropylmethyl)-N-(3-fluoropyridin-4-yl)indazole-3-carboxamide |
Database Links ![]() |
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GtoPdb PubChem SID | 500839965 |
PubChem CID | 155688341 |
Search Google for chemical match using the InChIKey | GWAAPHZRSAMWJU-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | GWAAPHZRSAMWJU |
UniChem Compound Search for chemical match using the InChIKey | GWAAPHZRSAMWJU-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | GWAAPHZRSAMWJU-UHFFFAOYSA-N |