Synonyms: BAY 2413555 | BAY-2413555 | compound 27 [PMID: 39463278]
Compound class:
Synthetic organic
Comment: BAY2413555 is a positive allosteric modulator (PAM) of the M2 muscarinic acetylcholine receptor (M2R) that binds at an extracellular vestibule adjacent to the orthosteric ligand binding site [1]. It is proposed to restore autonomic balance in heart failure patients, in whom sympathetic overactivation and parasympathetic withdrawal drive disease progression. Although BAY2413555 was the first clinical lead of its class, the development program was discontinued due to preclinical toxicity findings.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
Synonyms ![]() |
BAY 2413555 | BAY-2413555 | compound 27 [PMID: 39463278] |
Database Links ![]() |
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GtoPdb PubChem SID | 504705456 |
PubChem CID | 172431614 |
Search Google for chemical match using the InChIKey | VTFWALACVWFKNO-OCJYXSBASA-N |
Search Google for chemicals with the same backbone | VTFWALACVWFKNO |
UniChem Compound Search for chemical match using the InChIKey | VTFWALACVWFKNO-OCJYXSBASA-N |
UniChem Connectivity Search for chemical match using the InChIKey | VTFWALACVWFKNO-OCJYXSBASA-N |