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disitamab vedotin   Click here for help

GtoPdb Ligand ID: 13716

Synonyms: Aidixi® | RC-48 | RC48-ADC
Approved drug
disitamab vedotin is an approved drug
Compound class: Antibody
Comment: Disitamab vedotin (RC48) is an anti-epidermal growth factor receptor 2 (ERBB2; HER2) antibody-drug conjugate (ADC) [4]. Its cytotoxic payload is the potent antimitotic agent monomethyl auristatin E (MMAE). Antibody binding blocks ERBB2 signalling and intracellular release of MMAE inhibits microtubule formation and induces apoptosis. The antibody may also mediate antibody-dependent cell-mediated cytotoxicity (ADCC).
Classification Click here for help
Compound class Antibody
Approved drug? Yes. China NMPA (2021)
International Nonproprietary Names Click here for help
INN number INN
10933 disitamab vedotin
Synonyms Click here for help
Aidixi® | RC-48 | RC48-ADC
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 896
Other databases
GtoPdb PubChem SID 507750350
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