GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

navepegritide   Click here for help

GtoPdb Ligand ID: 14293

Synonyms: TransCon CNP
Compound class: Peptide
Comment: Navepegritide (TransCon CNP) is a prodrug of a human C-type natriuretic peptide (CNP) analogue [1]. It comprises CNP(1-38) attached to an inert polyethylene glycol carrier via a cleavable linker [3]. CNP is a validated therapeutic agent for the treatment of patients with achondroplasia (see the approved CNP analogue vosoritide) [2]. Navepegritide is designed to provide sustained hormone release and continuous CNP exposure as a once-weekly therapy that is proposed to counterbalance the overactivated FGFR3 signaling pathway in achondroplasia [1].
Classification Click here for help
Compound class Peptide
International Nonproprietary Names Click here for help
INN number INN
11981 navepegritide
Synonyms Click here for help
TransCon CNP
Database Links Click here for help
Search PubMed clinical trials navepegritide
Search PubMed titles navepegritide
Search PubMed titles/abstracts navepegritide