PACAP-38   Click here for help

GtoPdb Ligand ID: 2258

Synonyms: pituitary adenylate cyclase activating polypeptide-38
Comment: Sequences of human, mouse, rat and sheep PACAP-38 are identical.

PACAP-38 has been proposed as a novel target for the teament of migraine [6]. In response, Alder BioPharmaceuticals have developed an anti-PACAP-38 monoclonal antibody (ALD1910) that has progressed to clinical evaluation (NCT04197349).
Species: Human, Mouse, Rat
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Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Neuropeptides
Synonyms Click here for help
pituitary adenylate cyclase activating polypeptide-38
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
ADCYAP1 adenylate cyclase activating polypeptide 1 Human prepro-PACAP adenylate cyclase activating polypeptide 1 (pituitary), PACAP
Adcyap1 adenylate cyclase activating polypeptide 1 Mouse prepro-PACAP PACAP
Adcyap1 adenylate cyclase activating polypeptide 1 Rat prepro-PACAP adenylate cyclase activating polypeptide 1, adenylate cyclase activating polypeptide 1 (pituitary), Pacap, pituitary adenylate cyclase-activating polypeptide, pituitary adenylate cyclase activating polypeptide 1, pituitary adenylate cyclase-activating polypeptide precursor (Pacap), rat pituitary adenylate cyclase activating polypeptide 1
Database Links Click here for help
GtoPdb PubChem SID 135651850
UniProtKB O70176 (Mm), P18509 (Hs), P13589 (Rn)