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bicuculline   Click here for help

GtoPdb Ligand ID: 2312

Synonyms: bicuculline methiodide
PDB Ligand
Compound class: Natural product
Comment: Bicuculline is a phthalide-isoquinoline compound that was first isolated from the perennial herbaceous Dicentra cucullaria plant. It is also found in other plants.
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Ligand Activity Visualisation Charts

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View interactive charts of activity data across species

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 66.46
Molecular weight 367.11
XLogP 2.51
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CN1CCc2c(C1C1OC(=O)c3c1ccc1c3OCO1)cc1c(c2)OCO1
Isomeric SMILES CN1CCc2c([C@H]1[C@@H]1OC(=O)c3c1ccc1c3OCO1)cc1c(c2)OCO1
InChI InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
InChI Key IYGYMKDQCDOMRE-ZWKOTPCHSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Natural product
IUPAC Name Click here for help
(6R)-6-[(5S)-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-6H-furo[4,3-g][1,3]benzodioxol-8-one
Synonyms Click here for help
bicuculline methiodide
Database Links Click here for help
BindingDB Ligand 50000693
CAS Registry No. 485-49-4
ChEBI CHEBI:3092
ChEMBL Ligand CHEMBL417990
GtoPdb PubChem SID 135652669
PubChem CID 10237
RCSB PDB Ligand H0Z
Search Google for chemical match using the InChIKey IYGYMKDQCDOMRE-ZWKOTPCHSA-N
Search Google for chemicals with the same backbone IYGYMKDQCDOMRE
UniChem Compound Search for chemical match using the InChIKey IYGYMKDQCDOMRE-ZWKOTPCHSA-N
UniChem Connectivity Search for chemical match using the InChIKey IYGYMKDQCDOMRE-ZWKOTPCHSA-N
Wikipedia Bicuculline

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MedChemExpress
Bicuculline (links to external site)
Cat. No. HY-N0219