prucalopride   Click here for help

GtoPdb Ligand ID: 243

Synonyms: Motegrity® | R-093877 | R-108512 | Resolor®
Approved drug
prucalopride is an approved drug (EMA (2009), FDA (2018))
Compound class: Synthetic organic
Comment: Prucalopride is a serotonin 5-HT4 receptor agonist.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 76.82
Molecular weight 367.17
XLogP 1.56
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N
Isomeric SMILES COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N
InChI InChI=1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)
InChI Key ZPMNHBXQOOVQJL-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (EMA (2009), FDA (2018))
IUPAC Name Click here for help
4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide
International Nonproprietary Names Click here for help
INN number INN
7702 prucalopride
Synonyms Click here for help
Motegrity® | R-093877 | R-108512 | Resolor®
Database Links Click here for help
BindingDB Ligand 50122872
CAS Registry No. 179474-81-8 (source: Scifinder)
ChEMBL Ligand CHEMBL117287
DrugCentral Ligand 3502
GtoPdb PubChem SID 135650861
PubChem CID 3052762
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Wikipedia Prucalopride