angiotensin II   Click here for help

GtoPdb Ligand ID: 2504

Synonyms: ang II | Giapreza®
Approved drug
angiotensin II is an approved drug (FDA (2017))
Comment: Endogenous angiotensin II is a vasopressor.
Species: Human, Mouse, Rat
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2D Structure
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SMILES / InChI / InChIKey
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Canonical SMILES CCC(C(C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)C(NC(=O)C(C(C)C)NC(=O)C(NC(=O)C(CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C
Isomeric SMILES CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C
InChI InChI=1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1
InChI Key CZGUSIXMZVURDU-JZXHSEFVSA-N
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Neuropeptides
Approved drug? Yes (FDA (2017))
IUPAC Name Click here for help
(3S)-3-amino-4-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-hydroxy-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-(3H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
International Nonproprietary Names Click here for help
INN number INN
6707 angiotensin II
Synonyms Click here for help
ang II | Giapreza®
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
AGT angiotensinogen Human Angiotensinogen alpha-1 antiproteinase, antitrypsin, angiotensinogen (serpin peptidase inhibitor, clade A, member 8), SERPINA8
Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mouse Angiotensinogen angiotensinogen (serpin peptidase inhibitor, angiotensinogen (serpin peptidase inhibitor, clade A, member 8), angiotensin precursor, Aogen, Serpina8
Agt angiotensinogen Rat Angiotensinogen Ang, AngII, angiotensin II, angiotensinogen, angiotensinogen (PAT), angiotensinogen (serpin peptidase inhibitor, clade A, member 8), ANRT, MGC105326, PAT, serpin A8
Database Links Click here for help
BindingDB Ligand 82077
CAS Registry No. 4474-91-3 (source: WHO INN record)
ChEBI CHEBI:48432
ChEMBL Ligand CHEMBL408403
DrugCentral Ligand 5272
GtoPdb PubChem SID 53801076
PubChem CID 172198
Search Google for chemical match using the InChIKey CZGUSIXMZVURDU-JZXHSEFVSA-N
Search Google for chemicals with the same backbone CZGUSIXMZVURDU
Search PubMed clinical trials angiotensin II
Search PubMed titles angiotensin II
Search PubMed titles/abstracts angiotensin II
Search UniChem for chemical match using the InChIKey CZGUSIXMZVURDU-JZXHSEFVSA-N
Search UniChem for chemicals with the same backbone CZGUSIXMZVURDU
UniProtKB P01019 (Hs), P11859 (Mm), P01015 (Rn)
Wikipedia Angiotensin_II#Angiotensin_II

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Tocris
Angiotensin II
Cat. No. 1158