triamcinolone   Click here for help

GtoPdb Ligand ID: 2870

Synonyms: fluoxiprednisolone | Kenalog® | Nasacort®
Approved drug Immunopharmacology Ligand
triamcinolone is an approved drug (FDA (1957))
Compound class: Synthetic organic
Comment: Triamcinolone is a synthetic glucocorticoid anti-inflammatory drug. The approved drug is often administered in the formulation triamcinolone acetonide. Hexacetonide, furetonide and benetonide forms are also used in the clinic, and have individual INNs.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: triamcinolone

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 2
Topological polar surface area 115.06
Molecular weight 394.18
XLogP 0.67
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES OCC(=O)C1(O)C(O)CC2C1(C)CC(O)C1(C2CCC2=CC(=O)C=CC12C)F
Isomeric SMILES OCC(=O)[C@@]1(O)[C@H](O)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2CCC2=CC(=O)C=C[C@]12C)F
InChI InChI=1S/C21H27FO6/c1-18-6-5-12(24)7-11(18)3-4-13-14-8-15(25)21(28,17(27)10-23)19(14,2)9-16(26)20(13,18)22/h5-7,13-16,23,25-26,28H,3-4,8-10H2,1-2H3/t13-,14-,15+,16-,18-,19-,20-,21-/m0/s1
InChI Key GFNANZIMVAIWHM-OBYCQNJPSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1957))
IUPAC Name Click here for help
(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
International Nonproprietary Names Click here for help
INN number INN
755 triamcinolone
Synonyms Click here for help
fluoxiprednisolone | Kenalog® | Nasacort®
Database Links Click here for help
Specialist databases
Reactome Drug Reactome logo R-ALL-9679094
Reactome Reaction Reactome logo R-HSA-9678925
Other databases
BindingDB Ligand 41132
CAS Registry No. 124-94-7 (source: Scifinder)
ChEMBL Ligand CHEMBL1451
DrugBank Ligand DB00620
DrugCentral Ligand 2725
GtoPdb PubChem SID 135651276
PubChem CID 31307
Search Google for chemical match using the InChIKey GFNANZIMVAIWHM-OBYCQNJPSA-N
Search Google for chemicals with the same backbone GFNANZIMVAIWHM
Search PubMed clinical trials triamcinolone
Search PubMed titles triamcinolone
Search PubMed titles/abstracts triamcinolone
UniChem Compound Search for chemical match using the InChIKey GFNANZIMVAIWHM-OBYCQNJPSA-N
UniChem Connectivity Search for chemical match using the InChIKey GFNANZIMVAIWHM-OBYCQNJPSA-N
Wikipedia Triamcinolone