memantine   Click here for help

GtoPdb Ligand ID: 4253

Synonyms: Axura® | Ebixa® | Namenda®
Approved drug
memantine is an approved drug (EMA (2002), FDA (2003))
Compound class: Synthetic organic
Comment: Memantine is a non-competitive NMDA receptor antagonist approved for Alzheimer's disease but is also being studied in non-dementia psychiatric disorders [1] .
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 26.02
Molecular weight 179.17
XLogP 3.52
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES CC12CC3CC(C1)(C)CC(C2)(C3)N
Isomeric SMILES CC12CC3CC(C1)(C)CC(C2)(C3)N
InChI InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3
InChI Key BUGYDGFZZOZRHP-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (EMA (2002), FDA (2003))
IUPAC Name Click here for help
3,5-dimethyladamantan-1-amine
International Nonproprietary Names Click here for help
INN number INN
3952 memantine
Synonyms Click here for help
Axura® | Ebixa® | Namenda®
Database Links Click here for help
CAS Registry No. 19982-08-2 (source: Scifinder)
ChEMBL Ligand CHEMBL807
DrugBank Ligand DB01043
DrugCentral Ligand 1679
GtoPdb PubChem SID 178101070
PubChem CID 4054
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Wikipedia Memantine