Compound class:
Endogenous peptide in human, mouse or rat
Comment: Thrombin is a serine protease that acts as an agonist at the protease-activated GPCR family. Active thrombin is a complex between thrombin light chain and thrombin heavy chain. The chains are linked by a disulphide bond between cysteine residues at position 9 of the light chain and 118 of the heavy chain.
Species: Human
This ligand is also described as a target entry: coagulation factor II, thrombin |
References |
1. Austin KM, Covic L, Kuliopulos A. (2013)
Matrix metalloproteases and PAR1 activation. Blood, 121 (3): 431-9. [PMID:23086754] |