sildenafil   

GtoPdb Ligand ID: 4743

Synonyms: Viagra®
sildenafil is an approved drug (EMA & FDA (1998))
Compound class: Synthetic organic
Comment: Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor.
Marketed formulations may contain ildenafil citrate (PubChem CID 62853).
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2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 121.8
Molecular weight 474.2
XLogP 3.11
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES CCCc1nn(c2c1[nH]c(nc2=O)c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC1)C)C
Isomeric SMILES CCCc1nn(c2c1[nH]c(nc2=O)c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC1)C)C
InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)
InChI Key BNRNXUUZRGQAQC-UHFFFAOYSA-N
Classification
Compound class Synthetic organic
Approved drug? Yes (EMA & FDA (1998))
IUPAC Name
5-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-1-methyl-3-propyl-1H,4H,7H-pyrazolo[4,3-d]pyrimidin-7-one
International Nonproprietary Names
INN number INN
7374 sildenafil
Synonyms
Viagra®
Database Links
CAS Registry No. 139755-83-2 (source: Scifinder)
ChEBI CHEBI:9139
ChEMBL Ligand CHEMBL192
DrugBank Ligand DB00203
DrugCentral Ligand 2441
GtoPdb PubChem SID 178101454
PubChem CID 5212
RCSB PDB Ligand VIA
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SynPHARM 13777 (in complex with phosphodiesterase 5A)
Wikipedia Sildenafil