growth hormone 1   Click here for help

GtoPdb Ligand ID: 4943

Synonyms: NutropinAq® | Omnitrope® | Saizen® | somatotropin
Approved drug
growth hormone 1 is an approved drug (FDA (1976), EMA (2001))
Compound class: Endogenous peptide in human, mouse or rat
Comment: Human growth hormone 1 (somatropin) produced by recombinant technology is an approved drug with the INN somatropin. This has identical 191-amino acid sequence to the endogenous hormone.

Biosimilar drug: The EMA approved the biosimilar named Omnitrope (Sandoz GmbH) in 2006.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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View more information in the IUPHAR Pharmacology Education Project: growth hormone 1

Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Approved drug? Yes (FDA (1976), EMA (2001))
International Nonproprietary Names Click here for help
INN number INN
239 somatropin
Synonyms Click here for help
NutropinAq® | Omnitrope® | Saizen® | somatotropin
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
GH1 growth hormone 1 Human prepro-growth hormone 1 GH, GHN, GH-N, hGH-N, pituitary growth hormone
Database Links Click here for help
CAS Registry No. 12629-01-5 (source: Scifinder)
DrugBank Ligand DB00052 (Hs)
Ensembl Gene ENSG00000189162 (Hs)
GtoPdb PubChem SID 178101641
Human Protein Atlas ENSG00000189162 (Hs)
Search PubMed clinical trials somatropin
Search PubMed titles somatropin
Search PubMed titles/abstracts somatropin
UniProtKB P01241 (Hs)
Wikipedia Growth_hormone_1