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IL-23A   Click here for help

GtoPdb Ligand ID: 4989

Synonyms: IL-23p19 | IL23A | interleukin-23 subunit alpha | interleukin-23A
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: IL-23 is a heterodimeric cytokine, sharing a common p40 subunit with IL-12, but having a unique p19 subunit (IL23A).
Species: Human
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
brazikumab Peptide Primary target of this compound Hs Antibody Binding >11.4 pKd - 6
⤷ pKd >11.4 (Kd <4x10-12 M) [6]
Description: Measured using KinExA technology (a kinetic exclusion assay)
risankizumab Peptide Approved drug Hs Antibody Binding 10.4 – 11.0 pKd - 5,7
⤷ pKd >11.0 (Kd <1x10-11 M) [5]
pKd 10.4 (Kd 4.3x10-11 M) [7]
mirikizumab Peptide Approved drug Primary target of this compound Hs Antibody Binding 10.7 pKd - 2
⤷ pKd 10.7 (Kd 2.1x10-11 M) [2]
Description: Affinity binding measurement by surface plasmon resonance (BIAcore).
guselkumab Peptide Approved drug Hs Antibody Binding 10.1 pKd - 7
⤷ pKd 10.1 (Kd 7.7x10-11 M) [7]
tildrakizumab Peptide Approved drug Hs Antibody Binding 9.5 – 9.5 pKd - 4,7
⤷ pKd 9.5 (Kd 2.86x10-10 M) [7]
pKd 9.5 (Kd 2.97x10-10 M) [4]
Description: Binding affinity constant for clone 13B8-b CDRH2-b.