|
|
|
5-HT2A receptor
|
|
|
Hs |
Agonist |
Full agonist |
8.9 |
pKd |
- |
75 |
|
⤷ |
pKd
8.9
[75]
|
5-HT4 receptor
|
|
|
Hs |
Agonist |
Full agonist |
8.4 – 8.8 |
pKd |
- |
10 |
|
⤷ |
pKd
8.4 – 8.8
[10]
|
5-HT1F receptor
|
|
|
Hs |
Agonist |
Full agonist |
8.0 |
pKd |
- |
3 |
|
⤷ |
pKd
8.0
[3]
|
5-HT1B receptor
|
|
|
Hs |
Agonist |
Full agonist |
7.5 – 8.4 |
pKd |
- |
66,84 |
|
⤷ |
pKd
7.5 – 8.4
[66,84]
|
5-HT6 receptor
|
|
|
Rn |
Agonist |
Full agonist |
7.9 |
pKd |
- |
13 |
|
⤷ |
pKd
7.9
[13]
|
5-HT4 receptor
|
|
|
Rn |
Agonist |
Full agonist |
7.7 |
pKd |
- |
2 |
|
⤷ |
pKd
7.7
[2]
|
5-HT1A receptor
|
|
|
Hs |
Agonist |
Full agonist |
9.1 – 9.7 |
pKi |
- |
41,61-65 |
|
⤷ |
pKi
9.1 – 9.7
[41,61-65]
|
5-HT7 receptor
|
|
|
Rn |
Agonist |
Full agonist |
8.7 – 9.2 |
pKi |
- |
71,74 |
|
⤷ |
pKi
8.7 – 9.2
[71,74]
|
5-HT7 receptor
|
|
|
Hs |
Agonist |
Full agonist |
8.1 – 9.6 |
pKi |
- |
7,35,39,45,78 |
|
⤷ |
pKi
8.1 – 9.6
[7,35,39,45,78]
|
5-HT1D receptor
|
|
|
Hs |
Agonist |
Full agonist |
8.0 – 9.0 |
pKi |
- |
22,34,48,62,72,83-84 |
|
⤷ |
pKi
8.0 – 9.0
[22,34,48,62,72,83-84]
|
5-HT7 receptor
|
|
|
Mm |
Agonist |
Full agonist |
8.3 |
pKi |
- |
67 |
|
⤷ |
pKi
8.3
[67]
|
5-HT1B receptor
|
|
|
Hs |
Agonist |
Full agonist |
7.4 – 9.0 |
pKi |
- |
22,60,62,72,83-84 |
|
⤷ |
pKi
7.4 – 9.0
[22,60,62,72,83-84]
|
5-HT2B receptor
|
|
|
Hs |
Agonist |
Full agonist |
7.9 – 8.4 |
pKi |
- |
8,43,46,52,70 |
|
⤷ |
pKi
7.9 – 8.4
[8,43,46,52,70]
|
5-HT1B receptor
|
|
|
Mm |
Agonist |
Full agonist |
8.1 |
pKi |
- |
50 |
|
⤷ |
pKi
8.1
[50]
|
5-ht1e receptor
|
|
|
Hs |
Agonist |
Full agonist |
8.0 – 8.2 |
pKi |
- |
3,6,25,53 |
|
⤷ |
pKi
8.0 – 8.2
[3,6,25,53]
|
5-HT2B receptor
|
|
|
Rn |
Agonist |
Full agonist |
8.0 |
pKi |
- |
80 |
|
⤷ |
pKi
8.0
[80]
|
5-HT1F receptor
|
|
|
Hs |
Agonist |
Full agonist |
7.7 – 8.0 |
pKi |
- |
1,3,81 |
|
⤷ |
pKi
7.7 – 8.0
[1,3,81]
|
5-HT2C receptor
|
|
|
Hs |
Agonist |
Full agonist |
6.8 – 8.6 |
pKi |
- |
26,31,42-43,52 |
|
⤷ |
pKi
6.8 – 8.6
[26,31,42-43,52]
|
5-HT4 receptor
|
|
|
Rn |
Agonist |
Full agonist |
6.7 – 8.2 |
pKi |
- |
2,16,32 |
|
⤷ |
pKi
6.7 – 8.2
[2,16,32]
|
5-HT2C receptor
|
|
|
Rn |
Agonist |
Full agonist |
6.7 – 7.9 |
pKi |
- |
36,70 |
|
⤷ |
pKi
6.7 – 7.9
[36,70]
|
5-HT6 receptor
|
|
|
Rn |
Agonist |
Full agonist |
6.6 – 7.9 |
pKi |
- |
13-15,59 |
|
⤷ |
pKi
6.6 – 7.9
[13-15,59]
|
5-HT2A receptor
|
|
|
Hs |
Agonist |
Full agonist |
6.0 – 8.4 |
pKi |
- |
4,18,40,43,52,75 |
|
⤷ |
pKi
6.0 – 8.4
[4,18,40,43,52,75]
|
5-HT4 receptor
|
|
|
Mm |
Agonist |
Full agonist |
7.2 |
pKi |
- |
20 |
|
⤷ |
pKi
7.2
[20]
|
5-HT6 receptor
|
|
|
Hs |
Agonist |
Full agonist |
6.8 – 7.5 |
pKi |
- |
12,15,44 |
|
⤷ |
pKi
6.8 – 7.5
[12,15,44]
|
5-HT5A receptor
|
|
|
Hs |
Agonist |
Full agonist |
6.7 – 6.9 |
pKi |
- |
33,68 |
|
⤷ |
pKi
6.7 – 6.9
[33,68]
|
5-HT5A receptor
|
|
|
Rn |
Agonist |
Full agonist |
6.6 |
pKi |
- |
30 |
|
⤷ |
pKi
6.6
[30]
|
5-HT4 receptor
|
|
|
Hs |
Agonist |
Full agonist |
5.9 – 7.0 |
pKi |
- |
5,8,10-11,19,55-57,69,79 |
|
⤷ |
pKi
5.9 – 7.0
[5,8,10-11,19,55-57,69,79]
|
5-HT5A receptor
|
|
|
Mm |
Agonist |
Full agonist |
6.0 – 6.6 |
pKi |
- |
33,51,85 |
|
⤷ |
pKi
6.0 – 6.6
[33,51,85]
|
5-HT2A receptor
|
|
|
Rn |
Agonist |
Full agonist |
6.0 – 6.5 |
pKi |
- |
27,70,73 |
|
⤷ |
pKi
6.0 – 6.5
[27,70,73]
|
D5 receptor
|
|
|
Hs |
Agonist |
Full agonist |
5.5 |
pKi |
- |
77 |
|
⤷ |
pKi
5.5
[77]
|
D1 receptor
|
|
|
Hs |
Agonist |
Partial agonist |
5.0 |
pKi |
- |
77 |
|
⤷ |
pKi
5.0
[77]
|
5-HT1F receptor
|
|
|
Rn |
Agonist |
Full agonist |
7.2 |
pIC50 |
- |
49 |
|
⤷ |
pIC50
7.2
[49]
|
|