TGFβ1   

GtoPdb Ligand ID: 5060

Synonyms: TGF-beta-1 | transforming growth factor beta-1
Comment: TGFβ is a labile (half-life in vivo of 2-3 minutes) but highly potent cytokine. It plays a crucial role in immune regulation, and is highly fibriogenic.

The TGFβ1 gene encodes a proprotein that contains sequences for the latency-associated peptide (LAP) and the TGFβ peptide chains. Amino acids 1-29 form the signal peptide, 30-278 represent LAP and the C-terminal amino acids from 279-390 form TGFβ.

TGFβ is expressed at the cell surface (e.g. on Treg cells) as a highly glycosylated, furin-processed product in complex with the LAP protein. This complex does not have biological activity (so is a.k.a. latent TGFβ) and requires further processing to produce active TGFβ [4,6].
Species: Human
Classification
Compound class Endogenous peptide in human, mouse or rat
Synonyms
TGF-beta-1 | transforming growth factor beta-1
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
TGFB1 transforming growth factor beta 1 Human prepro-transforming growth factor beta-1 Camurati-Engelmann disease, CED, DPD1, TGFB, TGFbeta, transforming growth factor, beta 1
Database Links
CATH/Gene3D 2.10.90.10
Ensembl Gene ENSG00000105329 (Hs)
GtoPdb PubChem SID 178101753
Human Protein Atlas ENSG00000105329 (Hs)
UniProtKB P01137 (Hs)
Wikipedia TGFB1