VEGFA

Ligand id: 5085

Name: VEGFA

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Vascular endothelial growth factor (VEGF) family ligands
Synonyms
vascular endothelial growth factor A | vascular permeability factor (VPF) | VEGF-A
Comments
The active peptide is anti-parallel homodimer linked by disulphide bonds. VEGFA exists as four isoforms of 121, 165, 189 and 206 amino acids. The shortest variant contains the full VEGFR2 binding site but lacks domains that are involved in interactions with extracellular-matrix and co-receptors which are present in the longer isoforms [13-14].
A recombinant single-chain derivative of VEGFA121 (scVEGF) can be used experimentally as a fully functional peptide that binds and activates VEGFR2 in the same manner as endogenous VEGFA [1]. scVEGF can be labelled with a single fluorophore at its N-terminal, for use as a molecular probe [3].
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
VEGFA vascular endothelial growth factor A Human prepro-vascular endothelial growth factor A vascular endothelial growth factor, VEGF, VEGF-A, VPF
Database Links
CATH/Gene3D 2.10.160.10, 2.10.90.10
DrugBank Target P15692 (Hs)
Ensembl Gene ENSG00000112715 (Hs)
GtoPdb PubChem SID 178101778
Human Protein Atlas ENSG00000112715 (Hs)
UniProtKB P15692 (Hs)
Wikipedia VEGFA