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angiopoietin-2   Click here for help

GtoPdb Ligand ID: 5316

Synonyms: ANG-2
Compound class: Endogenous peptide in human, mouse or rat
Species: Human
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
zansecimab Peptide Primary target of this compound Hs Antibody Binding 11.0 pKd - 3
⤷ pKd 11.0 (Kd 1.1x10-11 M) [3]
Description: Binding affinity to human Ang2 measured using proprietary Kinetic Exclusion Assay (Kinexa®) methodology.
nesvacumab Peptide Primary target of this compound Hs Antibody Binding 10.7 pKd - 2
⤷ pKd 10.7 (Kd 1.8x10-11 M) [2]
vanucizumab Peptide Primary target of this compound Hs Antibody Binding 9.6 pKd - 1
⤷ pKd 9.6 (Kd 2.4x10-10 M) [1]
trebananib Peptide Primary target of this compound Hs Antibody Binding 9.2 pKd - 4
⤷ pKd 9.2 (Kd 6.7x10-10 M) [4]
faricimab Peptide Approved drug Primary target of this compound Hs Antibody Binding 7.7 pKd - 5
⤷ pKd 7.7 (Kd 2.2x10-8 M) [5]
Description: Binding affinity to a ANG-2 RBD-Fc fusion protein bt ITC
Ligand mentioned in the following text fields
Type XII RTKs: TIE family of angiopoietin receptors overview