angiotensin-(1-7)   

GtoPdb Ligand ID: 582

Synonyms: ang 1-7 | angiotensin 1-7 | TXA-127 | TXA127
Comment: Angiotensin (1-7) is a naturally occurring peptide that is cleaved from angiotensin 1 or angiotensin 2 by the actions of the enzymes ACE2 and MME respectively.
Species: Human, Mouse, Rat
2D Structure
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SMILES / InChI / InChIKey
Canonical SMILES CCC(C(C(=O)NC(C(=O)N1CCCC1C(=O)O)Cc1[nH]cnc1)NC(=O)C(NC(=O)C(C(C)C)NC(=O)C(NC(=O)C(CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C
Isomeric SMILES CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)O)Cc1[nH]cnc1)NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)N)CCCN=C(N)N)Cc1ccc(cc1)O)C
InChI InChI=1S/C41H62N12O11/c1-5-22(4)33(38(61)50-29(17-24-19-45-20-47-24)39(62)53-15-7-9-30(53)40(63)64)52-36(59)28(16-23-10-12-25(54)13-11-23)49-37(60)32(21(2)3)51-35(58)27(8-6-14-46-41(43)44)48-34(57)26(42)18-31(55)56/h10-13,19-22,26-30,32-33,54H,5-9,14-18,42H2,1-4H3,(H,45,47)(H,48,57)(H,49,60)(H,50,61)(H,51,58)(H,52,59)(H,55,56)(H,63,64)(H4,43,44,46)/t22-,26-,27-,28-,29-,30-,32-,33-/m0/s1
InChI Key PVHLMTREZMEJCG-GDTLVBQBSA-N
Classification
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Neuropeptides
IUPAC Name
(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-hydroxy-4-oxobutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(3H-imidazol-4-yl)propanoyl]pyrrolidine-2-carboxylic acid
Synonyms
ang 1-7 | angiotensin 1-7 | TXA-127 | TXA127
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
AGT angiotensinogen Human Angiotensinogen alpha-1 antiproteinase, antitrypsin, angiotensinogen (serpin peptidase inhibitor, clade A, member 8), SERPINA8
Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mouse Angiotensinogen angiotensinogen (serpin peptidase inhibitor, angiotensinogen (serpin peptidase inhibitor, clade A, member 8), angiotensin precursor, Aogen, Serpina8
Agt angiotensinogen Rat Angiotensinogen Ang, AngII, angiotensin II, angiotensinogen, angiotensinogen (PAT), angiotensinogen (serpin peptidase inhibitor, clade A, member 8), ANRT, MGC105326, PAT, serpin A8
Database Links
CAS Registry No. 51833-78-4
GtoPdb PubChem SID 135651614
PubChem CID 123805
Search Google for chemical match using the InChIKey PVHLMTREZMEJCG-GDTLVBQBSA-N
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Search UniChem for chemical match using the InChIKey PVHLMTREZMEJCG-GDTLVBQBSA-N
Search UniChem for chemicals with the same backbone PVHLMTREZMEJCG
UniProtKB P01019 (Hs), P11859 (Mm), P01015 (Rn)

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Tocris
Angiotensin (1-7)
Cat. No. 1562