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Synonyms: 10-DEBC | NCGC00167772-01
Compound class: Synthetic organic
Comment: This is compound 10B in  which describes its actions as an Akt (aka protein kinase B) inhibitor.
This compound is a thioridazine derivative. Thioridazine is a well known antipsychotic that acts as an antagonist of dopamine receptor activity. The compound also inhibits the kinase activity of Pim-1  and X-ray crystallography shows the compound binding to the Pim-1 pharmacophore.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|10-DEBC | NCGC00167772-01
|CAS Registry No.
|GtoPdb PubChem SID
|RCSB PDB Ligand
|Search Google for chemical match using the InChIKey
|Search Google for chemicals with the same backbone
|80328 (in complex with Pim-1 proto-oncogene, serine/threonine kinase)
|UniChem Compound Search for chemical match using the InChIKey
|UniChem Connectivity Search for chemical match using the InChIKey