GSK-3beta inhibitor I   Click here for help

GtoPdb Ligand ID: 5977

Synonyms: TDZD-8
Compound class: Synthetic organic
Comment: Using the code TDZD-8, this compound is used as a reference compound in [5]. TDZD-8 is the first reported non-ATP competitive GSK-3β inhibitor [4], with positive effects on glucose homeostasis in obese mice [3]. It is a thiadiazolidinone type compound.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 72.24
Molecular weight 222.05
XLogP 1.23
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES O=c1sn(c(=O)n1Cc1ccccc1)C
Isomeric SMILES O=c1sn(c(=O)n1Cc1ccccc1)C
InChI InChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
InChI Key JDSJDASOXWCHPN-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
Synonyms Click here for help
TDZD-8
Database Links Click here for help
Specialist databases
Reactome Drug Reactome logo R-ALL-9687653
Reactome Reaction Reactome logo R-HSA-9687724
Other databases
CAS Registry No. 327036-89-5
ChEMBL Ligand CHEMBL284861
GtoPdb PubChem SID 178102600
PubChem CID 4124851
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Tocris
TDZD 8
Cat. No. 6092