hydroxyurea   Click here for help

GtoPdb Ligand ID: 6822

Synonyms: Droxia® | Hydrea® | hydroxycarbamide | Siklos® | SQ-1089 | Xromi®
Approved drug PDB Ligand
hydroxyurea is an approved drug (FDA (1967), EMA (2007))
Compound class: Synthetic organic
Comment: Inhibits ribonucleoside-diphosphate reductase (RR1).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 3
Rotatable bonds 1
Topological polar surface area 75.35
Molecular weight 76.03
XLogP -1.61
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES NC(=O)NO
Isomeric SMILES NC(=O)NO
InChI InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
InChI Key VSNHCAURESNICA-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1967), EMA (2007))
WHO Essential Medicine WHO Essential Medicines List (EML) (22nd List, 2021). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
IUPAC Name Click here for help
hydroxyurea
International Nonproprietary Names Click here for help
INN number INN
1991 hydroxycarbamide
Synonyms Click here for help
Droxia® | Hydrea® | hydroxycarbamide | Siklos® | SQ-1089 | Xromi®
Database Links Click here for help
CAS Registry No. 127-07-1
ChEMBL Ligand CHEMBL467
DrugBank Ligand DB01005
DrugCentral Ligand 1399
GtoPdb PubChem SID 178103428
PubChem CID 3657
RCSB PDB Ligand NHY
Search Google for chemical match using the InChIKey VSNHCAURESNICA-UHFFFAOYSA-N
Search Google for chemicals with the same backbone VSNHCAURESNICA
Search PubMed clinical trials hydroxycarbamide
Search PubMed titles hydroxycarbamide
Search PubMed titles/abstracts hydroxycarbamide
UniChem Compound Search for chemical match using the InChIKey VSNHCAURESNICA-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey VSNHCAURESNICA-UHFFFAOYSA-N
Wikipedia Hydroxyurea