hydroxyurea   

GtoPdb Ligand ID: 6822

Synonyms: Droxia® | Hydrea® | hydroxycarbamide | Siklos® | SQ-1089 | Xromi®
hydroxyurea is an approved drug (FDA (1967), EMA (2007))
Compound class: Synthetic organic
Comment: Inhibits ribonucleoside-diphosphate reductase (RR1).
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 3
Rotatable bonds 1
Topological polar surface area 75.35
Molecular weight 76.03
XLogP -1.61
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES NC(=O)NO
Isomeric SMILES NC(=O)NO
InChI InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
InChI Key VSNHCAURESNICA-UHFFFAOYSA-N
Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1967), EMA (2007))
WHO Essential Medicine WHO Model List of Essential Medicines (21st List, 2019). Access PDF version.
IUPAC Name
hydroxyurea
International Nonproprietary Names
INN number INN
1991 hydroxycarbamide
Synonyms
Droxia® | Hydrea® | hydroxycarbamide | Siklos® | SQ-1089 | Xromi®
Database Links
CAS Registry No. 127-07-1
ChEMBL Ligand CHEMBL467
DrugBank Ligand DB01005
DrugCentral Ligand 1399
GtoPdb PubChem SID 178103428
PubChem CID 3657
RCSB PDB Ligand NHY
Search Google for chemical match using the InChIKey VSNHCAURESNICA-UHFFFAOYSA-N
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Search PubMed clinical trials hydroxycarbamide
Search PubMed titles hydroxycarbamide
Search PubMed titles/abstracts hydroxycarbamide
Search UniChem for chemical match using the InChIKey VSNHCAURESNICA-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone VSNHCAURESNICA
Wikipedia Hydroxyurea