thioguanine   Click here for help

GtoPdb Ligand ID: 6845

Synonyms: 6-mercaptoguanine | 6-thioguanine | Lanvis® | Tabloid®
Approved drug PDB Ligand
thioguanine is an approved drug (FDA (1966))
Compound class: Synthetic organic
Comment: Inhibits inosine-5'-monophosphate dehydrogenase 1.

thioguanine is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 0
Topological polar surface area 115.47
Molecular weight 167.03
XLogP 0.6
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES Nc1nc(=S)c2c([nH]1)nc[nH]2
Isomeric SMILES Nc1nc(=S)c2c([nH]1)nc[nH]2
InChI InChI=1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)
InChI Key WYWHKKSPHMUBEB-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1966))
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
IUPAC Name Click here for help
2-amino-6,7-dihydro-3H-purine-6-thione
International Nonproprietary Names Click here for help
INN number INN
1998 tioguanine
Synonyms Click here for help
6-mercaptoguanine | 6-thioguanine | Lanvis® | Tabloid®
Database Links Click here for help
Specialist databases
Reactome Drug Reactome logo R-ALL-9679095
Reactome Reaction Reactome logo R-HSA-9678749
Other databases
CAS Registry No. 154-42-7
ChEMBL Ligand CHEMBL727
DrugBank Ligand DB00352
DrugCentral Ligand 2632
GtoPdb PubChem SID 178103451
PubChem CID 2723601
RCSB PDB Ligand DX4
Search Google for chemical match using the InChIKey WYWHKKSPHMUBEB-UHFFFAOYSA-N
Search Google for chemicals with the same backbone WYWHKKSPHMUBEB
Search PubMed clinical trials tioguanine
Search PubMed titles tioguanine
Search PubMed titles/abstracts tioguanine
UniChem Compound Search for chemical match using the InChIKey WYWHKKSPHMUBEB-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey WYWHKKSPHMUBEB-UHFFFAOYSA-N
Wikipedia Thioguanine

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Tocris
6-Thioguanine (links to external site)
Cat. No. 4061