Classification
Compound class	Antibody
Ligand families/groups	Immune checkpoint modulators
Approved drug?	Yes (FDA (2005), EMA (2005))

International Nonproprietary Names
INN number	INN
8495	abatacept

Synonyms

BMS-188667 | CTLA4-IgG4m | Orencia® | RG-1046 | RG-2077

Comments

Abatacept is a recombinant protein fusing the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1) [3]. In essence, abatacept is a CTLA-4 mimetic, that enhances CTLA-4's inhibitory signal to T cells, thereby down-modulating T cell mediated inflammation.

Database Links
Specialist databases
IMGT/mAb-DB	212
Other databases
ChEMBL Ligand	CHEMBL1201823 (Hs)
DrugBank Ligand	DB01281
GtoPdb PubChem SID	178103473
PubChem SID	135355129
Search PubMed clinical trials	abatacept
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Wikipedia	Abatacept