abatacept   

GtoPdb Ligand ID: 6891

Synonyms: BMS-188667 | CTLA4-IgG4m | Orencia® | RG-1046 | RG-2077
abatacept is an approved drug (FDA (2005), EMA (2005))
Compound class: Antibody
Comment: Abatacept is a recombinant protein fusing the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1) [3]. In essence, abatacept is a CTLA-4 mimetic, that enhances CTLA-4's inhibitory signal to T cells, thereby down-modulating T cell mediated inflammation.

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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Classification
Compound class Antibody
Ligand families/groups Immune checkpoint modulators
Approved drug? Yes (FDA (2005), EMA (2005))
International Nonproprietary Names
INN number INN
8495 abatacept
Synonyms
BMS-188667 | CTLA4-IgG4m | Orencia® | RG-1046 | RG-2077
Database Links
Specialist databases
IMGT/mAb-DB 212
Other databases
ChEMBL Ligand CHEMBL1201823 (Hs)
DrugBank Ligand DB01281
GtoPdb PubChem SID 178103473
PubChem SID 135355129
Search PubMed clinical trials abatacept
Search PubMed titles abatacept
Search PubMed titles/abstracts abatacept
Wikipedia Abatacept