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gantenerumab   Click here for help

GtoPdb Ligand ID: 6933

Synonyms: R-1450 | RG-1450 | Ro-4909832
Compound class: Antibody
Comment: Gantenerumab targets aggregated forms of human amyloid β (Aβ) proteins Aβ42 and Aβ40. This is in contrast to solanezumab which targets soluble Aβ.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.
Protein sequence analysis reveals that gantenerumab is likely to be clone #7.9.H7 in patent US7794719 [1].
Bioactivity Comments
In vitro gantenerumab is able to effect clearance of Aβ from post-mortem human Alzheimer's diseased brain slices, and binds to Aβ plaques in the brains of AD model mice following systemic delivery [2].
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
amyloid β Primary target of this compound Hs Antibody Binding 9.1 – 9.6 pKd - 1
⤷ pKd 9.1 – 9.6 (Kd 7x10-10 – 2.4x10-10 M) [1]
Description: Binding to Aβ40 and Aβ42