GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

alpha-methyltyrosine   Click here for help

GtoPdb Ligand ID: 6956

Synonyms: Demser® | metyrosine | MK-781
Approved drug
alpha-methyltyrosine is an approved drug (FDA (1979))
Compound class: Synthetic organic
Comment: The US FDA approved name for this compound is metyrosine, an inhibitor of tyrosine 3-hydroxylase enzymatic activity.

alpha-methyltyrosine is commercially available from our sponsors

2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 3
Topological polar surface area 83.55
Molecular weight 195.09
XLogP -1.68
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

✖
Canonical SMILES Oc1ccc(cc1)CC(C(=O)O)(N)C
Isomeric SMILES Oc1ccc(cc1)C[C@@](C(=O)O)(N)C
InChI InChI=1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)/t10-/m0/s1
InChI Key NHTGHBARYWONDQ-JTQLQIEISA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. US FDA (1979)
IUPAC Name Click here for help
(2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid
International Nonproprietary Names Click here for help
INN number INN
4292 racemetirosine
Synonyms Click here for help
Demser® | metyrosine | MK-781
Database Links Click here for help
CAS Registry No. 672-87-7
ChEBI CHEBI:6912
ChEMBL Ligand CHEMBL1200862
DrugBank Ligand DB00765
DrugCentral Ligand 1792
GtoPdb PubChem SID 178103538
PubChem CID 441350
Search Google for chemical match using the InChIKey NHTGHBARYWONDQ-JTQLQIEISA-N
Search Google for chemicals with the same backbone NHTGHBARYWONDQ
Search PubMed clinical trials racemetirosine
Search PubMed titles racemetirosine
Search PubMed titles/abstracts racemetirosine
UniChem Compound Search for chemical match using the InChIKey NHTGHBARYWONDQ-JTQLQIEISA-N
UniChem Connectivity Search for chemical match using the InChIKey NHTGHBARYWONDQ-JTQLQIEISA-N
Wikipedia Metirosine

Product suppliers

View disclaimer

Sponsored products disclaimer

Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.

Links are provided in return for sponsorship, used to fund improvements to this database. The sponsorship account is managed and audited by the University of Edinburgh, a charitable body registered in Scotland, SC005336. If you are interested in sponsoring the database, please contact us.

✖

MedChemExpress
Metyrosine (links to external site)
Cat. No. HY-W015007