Synonyms: CS-0717 | GSK 525762A | GSK-525762 | GSK525762 | I-BET-762 | I-BET762
Compound class:
Synthetic organic
Comment: I-BET compounds such as molibresib are acetyl histone mimetics.
According to GSK's pipeline web resource they have terminated development of molibresib in cancer, as their emerging data did not support progression. ![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide |
International Nonproprietary Names ![]() |
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INN number | INN |
10533 | molibresib |
Synonyms ![]() |
CS-0717 | GSK 525762A | GSK-525762 | GSK525762 | I-BET-762 | I-BET762 |
Database Links ![]() |
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CAS Registry No. | 1260907-17-2 |
ChEMBL Ligand | CHEMBL1232461 |
GtoPdb PubChem SID | 178103612 |
PubChem CID | 46943432 |
RCSB PDB Ligand | EAM |
Search Google for chemical match using the InChIKey | AAAQFGUYHFJNHI-SFHVURJKSA-N |
Search Google for chemicals with the same backbone | AAAQFGUYHFJNHI |
Search PubMed clinical trials | molibresib |
Search PubMed titles | molibresib |
Search PubMed titles/abstracts | molibresib |
SynPHARM |
79905 (in complex with bromodomain containing 2) 79904 (in complex with bromodomain containing 4) |
UniChem Compound Search for chemical match using the InChIKey | AAAQFGUYHFJNHI-SFHVURJKSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | AAAQFGUYHFJNHI-SFHVURJKSA-N |