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cyclobenzaprine   Click here for help

GtoPdb Ligand ID: 7152

Synonyms: Amrix® | Fexmid | MK-130
Approved drug
cyclobenzaprine is an approved drug (FDA (1977))
Compound class: Synthetic organic
Comment: Cyclobenzaprine is a tricyclic antidepressant similar to amitriptyline. It acts as a skeletal muscle relaxant and central nervous system (CNS) depressant.
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View more information in the IUPHAR Pharmacology Education Project: cyclobenzaprine

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 3.24
Molecular weight 275.17
XLogP 5.21
No. Lipinski's rules broken 1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CN(CCC=C1c2ccccc2C=Cc2c1cccc2)C
Isomeric SMILES CN(CCC=C1c2ccccc2C=Cc2c1cccc2)C
InChI InChI=1S/C20H21N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-14H,7,15H2,1-2H3
InChI Key JURKNVYFZMSNLP-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. US FDA (1977)
IUPAC Name Click here for help
3-(dibenzo[1,2-a:1',2'-e][7]annulen-11-ylidene)-N,N-dimethylpropan-1-amine
International Nonproprietary Names Click here for help
INN number INN
791 cyclobenzaprine
Synonyms Click here for help
Amrix® | Fexmid | MK-130
Database Links Click here for help
CAS Registry No. 303-53-7
ChEMBL Ligand CHEMBL669
DrugBank Ligand DB00924
DrugCentral Ligand 751
GtoPdb PubChem SID 178103727
PubChem CID 2895
Search Google for chemical match using the InChIKey JURKNVYFZMSNLP-UHFFFAOYSA-N
Search Google for chemicals with the same backbone JURKNVYFZMSNLP
Search PubMed clinical trials cyclobenzaprine
Search PubMed titles cyclobenzaprine
Search PubMed titles/abstracts cyclobenzaprine
UniChem Compound Search for chemical match using the InChIKey JURKNVYFZMSNLP-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey JURKNVYFZMSNLP-UHFFFAOYSA-N
Wikipedia Cyclobenzaprine