moracizine   Click here for help

GtoPdb Ligand ID: 7244

Synonyms: EN-313 | Ethmozine® | moricizine
Approved drug
moracizine is an approved drug (FDA (1990))
Compound class: Synthetic organic
Comment: Moracizine is a phenothiazine derivative class Ic antiarrhythmic drug. Marketing by the original manufacturer has been discontinued.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 99.9
Molecular weight 427.16
XLogP 2.59
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CCOC(=Nc1ccc2c(c1)N(C(=O)CCN1CCOCC1)c1c(S2)cccc1)O
Isomeric SMILES CCOC(=Nc1ccc2c(c1)N(C(=O)CCN1CCOCC1)c1c(S2)cccc1)O
InChI InChI=1S/C22H25N3O4S/c1-2-29-22(27)23-16-7-8-20-18(15-16)25(17-5-3-4-6-19(17)30-20)21(26)9-10-24-11-13-28-14-12-24/h3-8,15H,2,9-14H2,1H3,(H,23,27)
InChI Key FUBVWMNBEHXPSU-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. FDA (1990)
Withdrawn drug? Yes
IUPAC Name Click here for help
N-{10-[3-(morpholin-4-yl)propanoyl]-10H-phenothiazin-2-yl}ethoxycarboximidic acid
International Nonproprietary Names Click here for help
INN number INN
2998 moracizine
Synonyms Click here for help
EN-313 | Ethmozine® | moricizine
Database Links Click here for help
CAS Registry No. 31883-05-3
ChEMBL Ligand CHEMBL1075
DrugBank Ligand DB00680
DrugCentral Ligand 1842
GtoPdb PubChem SID 178103818
PubChem CID 34633
Search Google for chemical match using the InChIKey FUBVWMNBEHXPSU-UHFFFAOYSA-N
Search Google for chemicals with the same backbone FUBVWMNBEHXPSU
Search PubMed clinical trials moracizine
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UniChem Compound Search for chemical match using the InChIKey FUBVWMNBEHXPSU-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey FUBVWMNBEHXPSU-UHFFFAOYSA-N
Wikipedia Moracizine