trimethadione   Click here for help

GtoPdb Ligand ID: 7316

Synonyms: Tridione®
Approved drug
trimethadione is an approved drug (FDA (1946))
Compound class: Synthetic organic
Comment: Trimethadione is an anticonvulsant.
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: trimethadione

2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 46.61
Molecular weight 143.06
XLogP -0.01
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

✖
Canonical SMILES O=C1OC(C(=O)N1C)(C)C
Isomeric SMILES O=C1OC(C(=O)N1C)(C)C
InChI InChI=1S/C6H9NO3/c1-6(2)4(8)7(3)5(9)10-6/h1-3H3
InChI Key IRYJRGCIQBGHIV-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1946))
Withdrawn drug? Yes
IUPAC Name Click here for help
trimethyl-1,3-oxazolidine-2,4-dione
International Nonproprietary Names Click here for help
INN number INN
1714 trimethadione
Synonyms Click here for help
Tridione®
Database Links Click here for help
CAS Registry No. 127-48-0
ChEMBL Ligand CHEMBL695
DrugBank Ligand DB00347
DrugCentral Ligand 2751
GtoPdb PubChem SID 178103889
PubChem CID 5576
Search Google for chemical match using the InChIKey IRYJRGCIQBGHIV-UHFFFAOYSA-N
Search Google for chemicals with the same backbone IRYJRGCIQBGHIV
Search PubMed clinical trials trimethadione
Search PubMed titles trimethadione
Search PubMed titles/abstracts trimethadione
UniChem Compound Search for chemical match using the InChIKey IRYJRGCIQBGHIV-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey IRYJRGCIQBGHIV-UHFFFAOYSA-N
Wikipedia Trimethadione