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siltuximab   Click here for help

GtoPdb Ligand ID: 7396

Synonyms: cLLB8 | CNTO 328 | Sylvant®
Approved drug Immunopharmacology Ligand
siltuximab is an approved drug (EMA & FDA (2014))
Compound class: Antibody
Comment: Siltuximab is a monoclonal antibody targeting interleukin 6 (IL-6) [6].
Peptide sequences for the heavy and light chains of this antibody are annotated in its IMGT/mAb-DB record. The invention of siltuximab is claimed in patent US7291721 [2].
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
IL-6 Primary target of this compound Hs Antibody Binding 10.2 pKd - 2
⤷ pKd 10.2 (Kd 5.7x10-11 M) [2]