2-PMAP   Click here for help

GtoPdb Ligand ID: 7530

Synonyms: AGN-PC-0031SD | ARN-2966
Compound class: Synthetic organic
Comment: 2-PMAP is an investigational compound for Alzheimer's disease (AD). A recent study has demonstrated that this compound crosses the blood-brain barrier and reduces levels of full-length amyloid precursor protein (APP) and amyloid beta (Aβ) deposition in the brains of AD model mice without causing significant toxicity [1]. This is accompanied by reduced Aβ pathology and rescue of memory deficit in AD model mice via an inhibitory effect on mRNA translation. This compound may exist as a tautomer with PubChem CID 68604369.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 45.15
Molecular weight 200.09
XLogP 2.24
No. Lipinski's rules broken 0
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Canonical SMILES Oc1ccccc1NCc1ccccn1
Isomeric SMILES Oc1ccccc1NCc1ccccn1
InChI InChI=1S/C12H12N2O/c15-12-7-2-1-6-11(12)14-9-10-5-3-4-8-13-10/h1-8,14-15H,9H2
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
Synonyms Click here for help
AGN-PC-0031SD | ARN-2966
Database Links Click here for help
CAS Registry No. 102212-26-0 (source: SciFinder)
GtoPdb PubChem SID 187051831
PubChem CID 14936865
Search Google for chemical match using the InChIKey GXJRVWZNMZGWAQ-UHFFFAOYSA-N
Search Google for chemicals with the same backbone GXJRVWZNMZGWAQ
UniChem Compound Search for chemical match using the InChIKey GXJRVWZNMZGWAQ-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey GXJRVWZNMZGWAQ-UHFFFAOYSA-N