Synonyms: compound 1g [PMID: 24900456] | SAR 1118 | SAR-1118 | SAR-1118-023 | Xiidra®
lifitegrast is an approved drug (FDA (2016))
Compound class:
Synthetic organic
Comment: It is postulated that lifitegrast (SAR 1118) interacts with the lymphocyte function-associated antigen-1 (LFA-1) to inhbit the LFA-1/ICAM-1 adhesion interaction and was approved for the treatment of Dry Ey in 2016 [7,9]. LFA-1 is a heterodimeric member of the β2 integrin family which is essential for adhesion, migration, and proliferation of T cells at sites of inflammation, and is involved in T cell specific immune responses through the formation of adhesive interactions and immunological synapses. Intercellular adhesion molecule‑1 (ICAM‑1) is the cognate ligand of LFA-1.The compound formulation is claimed in patent WO2014100135 [7].
|
|
Classification ![]() |
|
Compound class | Synthetic organic |
Approved drug? | Yes (FDA (2016)) |
Approved drug? | Yes. FDA (2016) |
IUPAC Name ![]() |
(2S)-2-[[2-(1-benzofuran-6-carbonyl)-5,7-dichloro3,4-dihydro-1H-isoquinoline-6-carbonyl]amino]-3-(3-methylsulfonylphenyl)propanoic acid |
International Nonproprietary Names ![]() |
|
INN number | INN |
9584 | lifitegrast |
Synonyms ![]() |
compound 1g [PMID: 24900456] | SAR 1118 | SAR-1118 | SAR-1118-023 | Xiidra® |
Database Links ![]() |
|
BindingDB Ligand | 50386331 |
CAS Registry No. | 1025967-78-5 |
ChEMBL Ligand | CHEMBL2048028 |
DrugCentral Ligand | 5174 |
GtoPdb PubChem SID | 187051834 |
PubChem CID | 11965427 |
Search Google for chemical match using the InChIKey | JFOZKMSJYSPYLN-QHCPKHFHSA-N |
Search Google for chemicals with the same backbone | JFOZKMSJYSPYLN |
Search PubMed clinical trials | lifitegrast |
Search PubMed titles | lifitegrast |
Search PubMed titles/abstracts | lifitegrast |
UniChem Compound Search for chemical match using the InChIKey | JFOZKMSJYSPYLN-QHCPKHFHSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | JFOZKMSJYSPYLN-QHCPKHFHSA-N |
Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.
Links are provided in return for sponsorship, used to fund improvements to this database. The sponsorship account is managed and audited by the University of Edinburgh, a charitable body registered in Scotland, SC005336. If you are interested in sponsoring the database, please contact us.
✖
Lifitegrast (links to external site)
Cat. No. HY-19344 |