Synonyms: norquetiapine
Compound class:
Synthetic organic
Comment: N-desalkylquetiapine is an active metabolite of the antidepressant quetiapine. N-desalkylquetiapine is approximately 100-fold more potent than quetiapine in inhibition of the norepinephrine reuptake transporter (NET) [1-2]. This acts to increase dopamine levels in the frontal cortex and adds to the compound's antidepressant effect [1,3].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
6-piperazin-1-ylbenzo[b][1,5]benzothiazepine |
Synonyms ![]() |
norquetiapine |
Database Links ![]() |
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GtoPdb PubChem SID | 187051846 |
PubChem CID | 11369918 |
Search Google for chemical match using the InChIKey | JLOAJISUHPIQOX-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | JLOAJISUHPIQOX |
UniChem Compound Search for chemical match using the InChIKey | JLOAJISUHPIQOX-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | JLOAJISUHPIQOX-UHFFFAOYSA-N |