lofepramine   Click here for help

GtoPdb Ligand ID: 7551

Synonyms: Gamanil ® | Lomont ® | WHR-2908A
Approved drug
lofepramine is an approved drug
Compound class: Synthetic organic
Comment: Marketed formulations may contain lofepramine hydrochloride (PubChem CID 33611).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 7
Topological polar surface area 23.55
Molecular weight 418.18
XLogP 6.01
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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Canonical SMILES CN(CC(=O)c1ccc(cc1)Cl)CCCN1c2ccccc2CCc2c1cccc2
Isomeric SMILES CN(CC(=O)c1ccc(cc1)Cl)CCCN1c2ccccc2CCc2c1cccc2
InChI InChI=1S/C26H27ClN2O/c1-28(19-26(30)22-13-15-23(27)16-14-22)17-6-18-29-24-9-4-2-7-20(24)11-12-21-8-3-5-10-25(21)29/h2-5,7-10,13-16H,6,11-12,17-19H2,1H3
InChI Key SAPNXPWPAUFAJU-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes
Withdrawn drug? Yes
IUPAC Name Click here for help
1-(4-chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone
International Nonproprietary Names Click here for help
INN number INN
2909 lofepramine
Synonyms Click here for help
Gamanil ® | Lomont ® | WHR-2908A
Database Links Click here for help
CAS Registry No. 23047-25-8
ChEBI CHEBI:47782
ChEMBL Ligand CHEMBL87708
DrugCentral Ligand 1592
GtoPdb PubChem SID 223365887
PubChem CID 3947
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UniChem Compound Search for chemical match using the InChIKey SAPNXPWPAUFAJU-UHFFFAOYSA-N
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Wikipedia Lofepramine

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Tocris
Lofepramine
Cat. No. 2545