amfenac   

GtoPdb Ligand ID: 7565

Synonyms: AHR-5850D | Fenazox® (Japan)
amfenac is an approved drug
Compound class: Synthetic organic
Comment: Amfenac is the active metabolite of nepafenac. It is a potent non-steroidal antiinflammatory drug (NSAID) [2].
Marketed formulations may contain amfenac sodium (PubChem CID 23665728).
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 80.39
Molecular weight 255.09
XLogP 2.62
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES OC(=O)Cc1cccc(c1N)C(=O)c1ccccc1
Isomeric SMILES OC(=O)Cc1cccc(c1N)C(=O)c1ccccc1
InChI InChI=1S/C15H13NO3/c16-14-11(9-13(17)18)7-4-8-12(14)15(19)10-5-2-1-3-6-10/h1-8H,9,16H2,(H,17,18)
InChI Key SOYCMDCMZDHQFP-UHFFFAOYSA-N
Classification
Compound class Synthetic organic
Ligand families/groups Non-steroidal anti-inflammatory ligands
Approved drug? Yes
Prodrug nepafenac
IUPAC Name
2-[2-amino-3-(benzoyl)phenyl]acetic acid
International Nonproprietary Names
INN number INN
4363 amfenac
Synonyms
AHR-5850D | Fenazox® (Japan)
Comments
Amfenac is the active metabolite of nepafenac. It is a potent non-steroidal antiinflammatory drug (NSAID) [2].
Marketed formulations may contain amfenac sodium (PubChem CID 23665728).
Database Links
CAS Registry No. 51579-82-9
ChEBI CHEBI:75915
ChEMBL Ligand CHEMBL25146
GtoPdb PubChem SID 223365901
PubChem CID 2136
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Wikipedia Amfenac