edoxaban   Click here for help

GtoPdb Ligand ID: 7575

Synonyms: DU-176 | DU-176b | edoxaban tosylate | Lixiana® | Savaysa®
Approved drug
edoxaban is an approved drug (EMA & FDA (2015))
Compound class: Synthetic organic
Comment: Edoxaban is an oral, once-daily factor Xa inhibitor anticoagulant.
Marketed formulations contain edoxaban tosylate (PubChem CID 44610678).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 11
Hydrogen bond donors 3
Rotatable bonds 10
Topological polar surface area 164.87
Molecular weight 547.18
XLogP -0.22
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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Canonical SMILES CN1CCc2c(C1)sc(n2)C(=O)NC1CC(CCC1NC(=O)C(=O)Nc1ccc(cn1)Cl)C(=O)N(C)C
Isomeric SMILES CN1CCc2c(C1)sc(n2)C(=O)N[C@@H]1C[C@H](CC[C@@H]1NC(=O)C(=O)Nc1ccc(cn1)Cl)C(=O)N(C)C
InChI InChI=1S/C24H30ClN7O4S/c1-31(2)24(36)13-4-6-15(27-20(33)21(34)30-19-7-5-14(25)11-26-19)17(10-13)28-22(35)23-29-16-8-9-32(3)12-18(16)37-23/h5,7,11,13,15,17H,4,6,8-10,12H2,1-3H3,(H,27,33)(H,28,35)(H,26,30,34)/t13-,15-,17+/m0/s1
InChI Key HGVDHZBSSITLCT-JLJPHGGASA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (EMA & FDA (2015))
IUPAC Name Click here for help
N'-(5-chloropyridin-2-yl)-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-[(5-methyl6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine-2-carbonyl)amino]cyclohexyl]oxamide
International Nonproprietary Names Click here for help
INN number INN
8982 edoxaban
Synonyms Click here for help
DU-176 | DU-176b | edoxaban tosylate | Lixiana® | Savaysa®
Database Links Click here for help
Specialist databases
Reactome Drug Reactome logo R-ALL-9038742
Reactome Reaction Reactome logo R-HSA-9015122, R-HSA-9015111
Other databases
CAS Registry No. 480449-70-5
ChEMBL Ligand CHEMBL1269025
DrugCentral Ligand 4897
GtoPdb PubChem SID 223365911
PubChem CID 10280735
Search Google for chemical match using the InChIKey HGVDHZBSSITLCT-JLJPHGGASA-N
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Search UniChem for chemical match using the InChIKey HGVDHZBSSITLCT-JLJPHGGASA-N
Search UniChem for chemicals with the same backbone HGVDHZBSSITLCT
Wikipedia Edoxaban