Synonyms: AZD 3778 | AZD-3778
Compound class:
Synthetic organic
Comment: AZD3778 was an investigational chemokine receptor antagonist, being evaluated as a potentila treatment for asthma. However, the compound failed to show efficacy and development project was halted. A poor level of target engagement and sub-optimal pharmacodynamic activity due to the pharmacokinetic properties of the compound were likely causes. This compound is discussed in the AZ 2014 review paper [2].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
4-[4-(3,4-dichlorophenoxy)piperidin-1-yl]-N-(4-methylphenyl)sulfonylpiperidine-1-carboxamide |
Synonyms ![]() |
AZD 3778 | AZD-3778 |
Database Links ![]() |
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Specialist databases | |
GPCRdb Ligand | AZD3778 |
Other databases | |
CAS Registry No. | 1032129-23-9 (source: SciFinder) |
ChEMBL Ligand | CHEMBL2158814 |
GtoPdb PubChem SID | 223366014 |
PubChem CID | 11753159 |
Search Google for chemical match using the InChIKey | QVLZVRFIGXNZMN-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | QVLZVRFIGXNZMN |
UniChem Compound Search for chemical match using the InChIKey | QVLZVRFIGXNZMN-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | QVLZVRFIGXNZMN-UHFFFAOYSA-N |