AZD1332   Click here for help

GtoPdb Ligand ID: 7700

Synonyms: AZD 1332 | AZD-1332
Compound class: Synthetic organic
Comment: AZD1332 is an inhibitor of neurotrophic tyrosine kinase receptors trkA, B and C (aka neurotrophic tyrosine kinase, receptor, type 1, 2 and 3). This compound is included in AstaZeneca's Open Innovation Pharmacology Toolbox.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 7
Topological polar surface area 100.64
Molecular weight 391.13
XLogP 4.28
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES CC(Oc1n[nH]c(c1)Nc1nc(ncc1Cl)NC(c1ccc(cn1)F)C)C
Isomeric SMILES CC(Oc1n[nH]c(c1)Nc1nc(ncc1Cl)NC(c1ccc(cn1)F)C)C
InChI InChI=1S/C17H19ClFN7O/c1-9(2)27-15-6-14(25-26-15)23-16-12(18)8-21-17(24-16)22-10(3)13-5-4-11(19)7-20-13/h4-10H,1-3H3,(H3,21,22,23,24,25,26)
InChI Key LBVKEEFIPBQIMD-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
5-chloro-2-N-[1-(5-fluoropyridin-2-yl)ethyl]-4-N-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine
Synonyms Click here for help
AZD 1332 | AZD-1332
Database Links Click here for help
ChEMBL Ligand CHEMBL2007421
GtoPdb PubChem SID 223366033
PubChem CID 49831044
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