AZD6495   Click here for help

GtoPdb Ligand ID: 7711

Synonyms: AZD 6495 | AZD-6495
Compound class: Synthetic organic
Comment: AZD6495 is an investigational inhibitor of the colony stimulating factor-1 receptor (CSF-1R) tyrosine kinase [1]. It was developed as an antineoplastic agent. This compound is now included in AstaZeneca's Open Innovation Pharmacology Toolbox.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 83.72
Molecular weight 441.2
XLogP 3.29
No. Lipinski's rules broken 0
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Canonical SMILES CCOc1cc2ncc(c(c2cc1N1CCN(CC1)C)Nc1ccc(cc1F)F)C(=O)N
Isomeric SMILES CCOc1cc2ncc(c(c2cc1N1CCN(CC1)C)Nc1ccc(cc1F)F)C(=O)N
InChI InChI=1S/C23H25F2N5O2/c1-3-32-21-12-19-15(11-20(21)30-8-6-29(2)7-9-30)22(16(13-27-19)23(26)31)28-18-5-4-14(24)10-17(18)25/h4-5,10-13H,3,6-9H2,1-2H3,(H2,26,31)(H,27,28)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
Synonyms Click here for help
AZD 6495 | AZD-6495
Database Links Click here for help
ChEMBL Ligand CHEMBL481806
GtoPdb PubChem SID 223366044
PubChem CID 16755780
Search Google for chemical match using the InChIKey IBHNEKVLDKCEQY-UHFFFAOYSA-N
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UniChem Compound Search for chemical match using the InChIKey IBHNEKVLDKCEQY-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey IBHNEKVLDKCEQY-UHFFFAOYSA-N