AZD7325   Click here for help

GtoPdb Ligand ID: 7712

Synonyms: AZD 7325 | AZD-7325
Compound class: Synthetic organic
Comment: AZD7325 was developed as a positive allosteric modulator of the GABAA α2 and α3 channels and was investigated as a treatment for generalised anxiety disorder. This compound is now included in AstaZeneca's Open Innovation Pharmacology Toolbox.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 90.13
Molecular weight 354.15
XLogP 3.2
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES CCCNC(=O)c1nnc2c(c1N)cccc2c1c(F)cccc1OC
Isomeric SMILES CCCNC(=O)c1nnc2c(c1N)cccc2c1c(F)cccc1OC
InChI InChI=1S/C19H19FN4O2/c1-3-10-22-19(25)18-16(21)12-7-4-6-11(17(12)23-24-18)15-13(20)8-5-9-14(15)26-2/h4-9H,3,10H2,1-2H3,(H2,21,23)(H,22,25)
InChI Key KYDURMHFWXCKMW-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
4-amino-8-(2-fluoro-6-methoxyphenyl)-N-propylcinnoline-3-carboxamide
Synonyms Click here for help
AZD 7325 | AZD-7325
Database Links Click here for help
ChEMBL Ligand CHEMBL1783282
GtoPdb PubChem SID 223366045
PubChem CID 23581869
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