Compound class:
Synthetic organic
Comment: This is an MMP12-specific peptide sequence with the active inhibitor released upon enzyme cleavage as a three-step conversion predrug (this entry) > prodrug compound 5 [PMID: 24900526] > drug compound 1 [PMID: 24900526] [1]
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References |
1. Cobos-Correa A, Stein F, Schultz C. (2012)
Target-Activated Prodrugs (TAPs) for the Autoregulated Inhibition of MMP12. ACS Med Chem Lett, 3 (8): 653-7. [PMID:24900526] |