BV-6   

GtoPdb Ligand ID: 7914

Synonyms: BV6
Compound class: Synthetic organic
Comment: BV-6 is a bivalent SMAC mimetic which acts as a dual cIAP and XIAP inhibitor [1].
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 18
Hydrogen bond donors 8
Rotatable bonds 37
Topological polar surface area 239.28
Molecular weight 1204.74
XLogP 8.82
No. Lipinski's rules broken 4
SMILES / InChI / InChIKey
Canonical SMILES CNC(C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(c1ccccc1)c1ccccc1)C(=O)NCCCCCCNC(=O)C(C(c1ccccc1)c1ccccc1)NC(=O)C1CCCN1C(=O)C(C1CCCCC1)NC(=O)C(NC)C)C1CCCCC1)C
Isomeric SMILES CN[C@H](C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(c1ccccc1)c1ccccc1)C(=O)NCCCCCCNC(=O)[C@H](C(c1ccccc1)c1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C1CCCCC1)NC(=O)[C@@H](NC)C)C1CCCCC1)C
InChI InChI=1S/C70H96N10O8/c1-47(71-3)63(81)75-59(53-37-21-11-22-38-53)69(87)79-45-27-41-55(79)65(83)77-61(57(49-29-13-7-14-30-49)50-31-15-8-16-32-50)67(85)73-43-25-5-6-26-44-74-68(86)62(58(51-33-17-9-18-34-51)52-35-19-10-20-36-52)78-66(84)56-42-28-46-80(56)70(88)60(54-39-23-12-24-40-54)76-64(82)48(2)72-4/h7-10,13-20,29-36,47-48,53-62,71-72H,5-6,11-12,21-28,37-46H2,1-4H3,(H,73,85)(H,74,86)(H,75,81)(H,76,82)(H,77,83)(H,78,84)/t47-,48-,55-,56-,59-,60-,61-,62-/m0/s1
InChI Key DPXJXGNXKOVBJV-YLOPQIBLSA-N
Classification
Compound class Synthetic organic
IUPAC Name
(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-methylaminopropanoyl]amino]acetyl]-N-[(2S)-1-[6-[[(2S)-2-[[(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-methylaminopropanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-3,3-di(phenyl)propanoyl]amino]hexylamino]-1-oxo-3,3-di(phenyl)propan-2-yl]pyrrolidine-2-carboxamide
Synonyms
BV6
Database Links
CAS Registry No. 1001600-56-1
GtoPdb PubChem SID 249565597
PubChem CID 23657864
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