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These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Approved drug?||Yes (EMA & FDA (2017))|
|International Nonproprietary Names|
|Kevzara® | REGN88 | SAR153191|
|Sarilumab is a monoclonal antibody directed against the interleukin 6 receptor (IL6R).
Peptide sequence and structural information for this antibody are available from its IMGT/mAb-db record. Peptide sequence BLAST search using the heavy and light chain variable regions of sarilumab provides 100% matches to sequences covered by patent US7582298 , and to the antibody with designation VQ8F11-21.
|GtoPdb PubChem SID||249565679|
|Search PubMed clinical trials||sarilumab|
|Search PubMed titles||sarilumab|
|Search PubMed titles/abstracts||sarilumab|