Compound class:
Endogenous peptide in human, mouse or rat
Comment: Human CXCL6 is most closely related to CXCL5.
Species: Human
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
| Immunopharmacology Comments |
| CXCL6 is upregulated by IL-1β and downregulated by IFN-γ. It is a chemoattract for neutrophils and exhibits proangiogenic properties. It has actions in physiologic and pathologic processes. |
| Immunopharmacology Disease | |||
| Disease | X-Refs | Comment | References |
| Scleroderma |
Disease Ontology:
DOID:419 |
Serum CXCL6 levels are reported to positively correlate with the severity of dermal and pulmonary fibrosis and vascular symptoms in patients with systemic sclerosis (scleroderma). | 1 |
