Compound class:
Synthetic organic
Comment: Miridesap (CPHPC) is reported as a chemical which depletes the glycoprotein serum amyloid P component (SAP) in mice [1] and humans [2]. Intellectual property for the use of CPHPC has been licensed to GlaxoSmithKline who have coded the compound GSK2315698. Structurally, CPHPC is a simplified form of a captopril dimer [8]. Mechanistically miridesap cross-links pairs of SAP molecules in serum forming complexes that are rapidly cleared from the body and disrupts SAP binding to amyloid fibrils and neurofibrillary tangles [3]. SAP is a drug target for the treament of neurodegenerative diseases (amyloidoses) [7].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
|
Classification | |
Compound class | Synthetic organic |
IUPAC Name |
(2R)-1-[6-[(2R)-2-carboxypyrrolidin-1-yl]-6-oxohexanoyl]pyrrolidine-2-carboxylic acid |
International Nonproprietary Names | |
INN number | INN |
10363 | miridesap |
Synonyms | |
compound 52 [PMID 14998318] [8] | CPHPC | GSK2315698 | Ro 63-8695 [8] |
Database Links | |
CAS Registry No. | 224624-80-0 |
ChEMBL Ligand | CHEMBL25263 |
GtoPdb PubChem SID | 249565936 |
PubChem CID | 125516 |
RCSB PDB Ligand | GHE |
Search Google for chemical match using the InChIKey | HZLAWYIBLZNRFZ-VXGBXAGGSA-N |
Search Google for chemicals with the same backbone | HZLAWYIBLZNRFZ |
Search PubMed clinical trials | miridesap |
Search PubMed titles | miridesap |
Search PubMed titles/abstracts | miridesap |
SynPHARM | 81894 (in complex with amyloid P component, serum) |
UniChem Compound Search for chemical match using the InChIKey | HZLAWYIBLZNRFZ-VXGBXAGGSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | HZLAWYIBLZNRFZ-VXGBXAGGSA-N |
Wikipedia | CPHPC |