GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

delta like canonical Notch ligand 4   Click here for help

GtoPdb Ligand ID: 8452

Abbreviated name: DLL4
Compound class: Endogenous peptide in human, mouse or rat
Comment: DLL4 is a 685 amino acid, peptide Notch receptor ligand expressed on the membranes of vascular endothelial cells [4]. DLL4 is a molecular target for the development of anti-cancer therapies [3].
Species: Human
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
demcizumab Peptide Primary target of this compound Hs Antibody Binding 9.5 pKi - 1
⤷ pKi 9.5 (Ki 3.3x10-10 M) [1]