aTyr 1940   

GtoPdb Ligand ID: 8738

Synonyms: ATYR1940 | HRS(1-506) | Resolaris
Comment: aTyr 1940 is a recombinant 506 amino acid version of human histidyl-tRNA synthetase (cytoplasmic isoform 1) (HARS; P12081) [1]. HARS belongs to a novel group of naturally occurring proteins termed 'physiocrines' which are extracellular signaling regions of tRNA synthetases reported to modulate immune system pathways. Physiocrines are of interest to the pharmaceutical industry as molecular targets for immunomodulatory therapies (see patents WO2013123432 A2 and US20150093799 A1 for further details [1-2]). See also resokine, a shorter variant of aTyr 1940.
Classification
Compound class Peptide or derivative
Synonyms
ATYR1940 | HRS(1-506) | Resolaris
Database Links
GtoPdb PubChem SID 252827396